Fig. 5: PheWAS analysis of most important variants.
From: An explainable model of host genetic interactions linked to COVID-19 severity
a Phenotype categories displaying the greatest fraction of specific trait associations with variants enriched in severe versus asymptomatic patients; b scatter plot showing variant-specific traits associated within the “Respiratory or thoracic disease category”. Dot diameter is proportional to the model support for each variant. The color is proportional to the log-odds ratio of the variant in the two groups of the cohort. Labels are printed only associations with PheWAS P value <0.001 and PheWAS oddsratio >2.5 or for variants having non-zero coefficients in at least one XGBoost model.
