Fig. 5: Structural organization of CgMCA-ICa and CgMCA-IMg cation binding sites. | Communications Biology

Fig. 5: Structural organization of CgMCA-ICa and CgMCA-IMg cation binding sites.

From: Structural and molecular determinants of Candida glabrata metacaspase maturation and activation by calcium

Fig. 5

a, c. Positions of Ca2+ in yellow and the coordinating water molecule in red (CgMCA-ICa) respective to Sm3+ in green (TbMCA-Ib, PDB code: 4AFP) (a) and Mg2+A in purple (CgMCA-IMg) (b). Loop Gln185-Asp199 surrounding the Ca2+ (CgMCA-ICa) is shown in green (a, c), the disordered loop Cys162-Asp173 in TbMCA-Ib is shown in cyan (a) and loop Asp188-Gly196 in CgMCA-IMg is shown in gray (c). Schematic representation of the coordinated Sm3+ (b) and Mg2+A (d) as observed in the structures of TbMCA-Ib and CgMCA-IMg, respectively.

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