Table 4 Average TPM of coding and non-coding genes in the LD blocks of the most significant GWAS markers calculated for each bladder cancer cell line.

From: A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

Marker

Coding and non-coding genes

Control tissue

Bladder Ca

Transit. cell Ca

Squamous cell Ca

Ur. urothelial Ca

Mus. Inv. Urothelial Ca

rs1924557

LPHN2

6.87

17.47

24.25

11.00

5.00

1.32

rs4745

EFNA1

8.25

31.30

78.50

20.00

7.00

4.06

rs4745

SLC50A1

0.24

62.60

46.00

26.00

46.00

4.15

rs4745

DPM3

131.29

66.55

82.50

16.00

79.00

4.77

rs4745

KRTCAP2

170.89

18.95

15.75

10.00

16.00

11.37

rs6874700

ISL1

0.36

0.61

2.03

3.00

0.00

0.06

11:119964758

TRIM29

11.86

52.27

61.25

19.00

0.20

5.15

rs10862001

SYT1

0.06

4.30

8.13

4.00

0.40

1.05

rs10862001

PAWR

13.47

37.65

49.25

12.00

22.00

5.46

rs10853087

GOSR2

11.25

16.80

12.50

5.00

16.00

3.69

rs6874700

HMGB1P47

RNA-polyA-seq

0.00

0.00

0.00

0.00

RNA-polyA-seq

rs6874700

ISL1-DT

RNA-polyA-seq

0.11

0.20

0.5

0.00

RNA-polyA-seq

rs10853087

LINC01974

RNA-polyA-seq

0.04

0.00

0.00

0.00

RNA-polyA-seq

20:55165923

LINC01716

RNA-polyA-seq

0.01

0.00

0.00

0.00

RNA-polyA-seq

  1. urothelial carcinoma tissues and control bladder tissue.
  2. TPM for Non-coding genes in Control tissue and Muscolar invasive urothelial cancer do not show reads due to polyA-sequencing. Legend: Bladder tissue of a 3-year-old bladder donor (control tissue); Bladder carcinoma (Bladder Ca); Bladder transitional cell carcinoma (Transit. cell Ca); Bladder squamous cell carcinoma (Squamous Ca); Ureter urothelial carcinoma (Urothelial Ca); Bladder urothelial carcinoma (Bl. urothelial Ca); Muscle invasive urothelial cancer (Mus. Inv. Urothelial Ca); RNA-polyA-seq data do not include miRNAs or lincRNAs.