Fig. 8: Schematic representation illustrating summarized findings.
From: Reprogramming of pancreatic adenocarcinoma immunosurveillance by a microbial probiotic siderophore
Ferrichrome polarizes macrophages to an M1-like phenotype via TLR4 activation which results in production of proinflammatory signals. TLR4 activation by ferrichrome modulates iron metabolism via downregulation of iron export protein Fpn via endogenous production of hepcidin. Activation of M1-like macrophages drives an antitumor immune response against pancreatic tumor cells via increase infiltration of CD8 + T cell.
