Fig. 4: In vivo antitumor effects of P-LPK-CPT in CRC patient-derived xenografts.
From: Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer
a, b The size of tumors of different treatments after 26 days. Tumor volume changed after intravenous injection of the P-LPK-CPT conjugate (n = 8, means ± SD) (***p < 0.001, ****p < 0.0001). c HE staining showed that the tumor tissues of the P-LPK-CPT group were substantially replaced by connective tissues (arrowheads). d CPT signal (blue dots) was much stronger in the P-LPK-CPT tumor tissues. Red color was from propidium iodide (PI) for nuclear visualization. e, f Representative images (e) and quantification (f) of Cleaved caspase 3 immunofluorescence in colon tissues (n = 5, means ± SD) (CPT vs P-LPK-CPT, p = 0.0051; P-CON-CPT vs P-LPK-CPT, p = 0.0722; **p < 0.01).
