Table 2 Effect on the susceptibility to Sertoli cell-only (SCO) phenotype of the residues at position 13 of the HLA-DRβ1 molecule.

From: Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility

Residue

Frequency (%)

P

OR [95% CI]

Classical MHC alleles

SCO

Controls

Ser

51.40

37.75

1.32E−08

1.80 [1.47–2.21]

DRB1*03, DRB1*11, DRB1*13, DRB1*14,

Arg

8.65

14.07

7.93E−04

0.55 [0.38–0.78]

DRB1*15, DRB1*16

Tyr

11.45

15.43

3.86E−02

0.72 [0.52–0.98]

DRB1*07

Gly

3.51

5.36

9.71E−02

0.63 [0.37–1.09]

DRB1*08, DRB1*12

Phe

11.21

13.40

1.96E−01

0.81 [0.59–1.11]

DRB1*01, DRB1*09, DRB1*10

His

13.79

13.99

7.26E−01

0.95 [0.71–1.27]

DRB1*04

  1. The results of the combined analysis by logistic regression and the classical MHC alleles in our dataset that contain those amino acids are shown.
  2. OR odds ratio for the reference residue, CI confidence interval.
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