Table 1 Siglec-6 mAb characteristics.
From: Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
Clone | Binding Domain | Epitope Bin | Affinity (Kd) |
|---|---|---|---|
AK01 | 1 | A | 1.0 × 10−12 |
AK02 | 1 | C | 7.0 × 10−12 |
AK03 | 1 | A | 1.0 × 10−12 |
AK04 | 1 | A | 1.0 × 10−12 |
AK05 | 1 | B | 5.5 × 10−11 |
AK06 | 1 | B | 2.4 × 10−11 |
AK07 | 1 | C | 6.9 × 10−11 |
AK08 | 3 | D | 2.6 × 10−10 |
AK09 | 3 | D | 1.1 × 10−10 |
AK10 | 2 | E | 8.4 × 10−11 |
AK11 | 2 | E | 2.0 × 10−12 |
AK12 | 3 | D | 8.7 × 10−11 |
AK13 | 3 | D | 6.3 × 10−11 |
AK14 | 3 | D | 7.2 × 10−11 |
AK15 | 3 | ND | 1.0 × 10−9 |
AK16 | ND | ND | ND |
AK17 | ND | ND | ND |
AK18 | ND | ND | ND |
