Fig. 3: Gene expression changes upon targeted knockdown of Drosophila TFs in S2 cells. | Communications Biology

Fig. 3: Gene expression changes upon targeted knockdown of Drosophila TFs in S2 cells.

From: NetREX-CF integrates incomplete transcription factor data with gene expression to reconstruct gene regulatory networks

Fig. 3

a A heatmap summarizes differential gene expression between Drosophila S2 cells treated with TF RNAi versus control RNAi (dsRNA for E. coli LacZ gene). Columns. Depletion of 465 TFs. Rows. Gene expression changes in the log2 scale. Genes that are not differentially expressed from any of the TF RNAi experiments were not shown in this heatmap. The results are clustered using the k-means clustering method. b–e Results from Gene Ontology (GO) analysis for the clustered genes in (a). The four clusters with the largest gene sets are demonstrated. Circle size. A number of genes are associated with a specific GO term or hits. Circle color. Adjusted p value. f A histogram that summarizes numbers of differentially expressed genes. Vertical red line. Median of the observation.

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