Fig. 2: Multivariate locus discovery. | Communications Biology

Fig. 2: Multivariate locus discovery.

From: The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

Fig. 2

a Manhattan plot of the multivariate GWAS on all MRI-derived body composition measures, with the observed −log10(p) of each SNP shown on the y-axis. The x-axis shows the relative genomic location, grouped by chromosome, and the red dashed line indicates the whole-genome significance threshold of 5 × 10−8. The y-axis is clipped at −log10(p) = 75. b Heatmap showing −log10(p) of the association between the lead variants of MOSTest-identified independent loci (x-axis) and each of the individual MRI measures (y-axis). The values are capped at 7.5 (p = 5 × 10−8).

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