Fig. 6: ANGPTL2 is enriched in human fetal semilunar valves and associated with cell cycle and senescence pathways. | Communications Biology

Fig. 6: ANGPTL2 is enriched in human fetal semilunar valves and associated with cell cycle and senescence pathways.

From: Angiopoietin-like 2 is essential to aortic valve development in mice

Fig. 6

a Heatmap of genes expressed in human fetal semilunar valves and adult AoV leaflets. b Close-up view of the heatmap showing significant enrichment of ANGPTL2, HEY1 and NOTCH1 in fetal semilunar valves; *significantly expressed genes (FDR < 0.05 and log2 FC > 1.5). c Pathway enrichment for the turquoise heart valve gene module obtained from WGCNA.

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