Table 3 Effect of GSH on PV VLP thermostability.
|  | Temperature (°C) at which 50% D-Antigenicity was lost (Temperature difference between treated and non-treated samples) | |||
|---|---|---|---|---|
VLP Prep* | No GSH | +1 mM GSH | +5 mM GSH | +10 mM GSH |
IPV (type 3) | 50.0 °C |  |  |  |
MVA PV2 MEFSC6b | 52.0 °C | 55.0 °C (↑3 °C) | >55.0 °C (↑>3 °C) | >70.0 °C (↑>18 °C) |
MVA PV3 SktSC8 | 56.0 °C | 66.0 °C (↑10 °C) | 67.0 °C (↑11 °C) | 67.0 °C (↑11 °C) |
MVA wt PV2 | 34.5 °C | 40.5 °C (↑6 °C) | 41.5 °C (↑7 °C) | 42.5 °C (↑8 °C) |
MVA wt PV3 | 35.0 °C |  | 41.0 °C (↑6 °C) |  |
Yeast PV1 MahSC6b | 43.5 °C | 48.0 °C (↑4.5 °C) | 52.5 °C (↑9 °C) | 51.5 °C (↑8 °C) |
Yeast PV2 MEFSC6b | 45.5 °C | 48.0 °C (↑2.5 °C) | 50.0 °C (↑4.5 °C) | 50.0 °C (↑4.5 °C) |
Yeast PV3 SktSC8 | 55.0 °C | 55.5 °C (↑0.5 °C) | 53.0 °C (↓2 °C) | 55.0 °C (=) |
