Table 2 Meta-analysis results from the model adjusted for maternal age, parity, maternal education, maternal smoking and putative cellular heterogeneity, showing the 27 Bonferroni significant CpGs associated with maternal ppBMI.

From: A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

CpG

Results from the meta-analysis

Meta-analysis heterogeneity

Location Annotations

 

Beta

SE

95% CI

P-value

Adj. P-value

Direction

HetISq

HetDf

HetPVal

Chr

Pos

Closest Gene

Distance to closest Gene

Relation to Island

cg00423969

−0.00092

0.00015

−0.0012;−0.0006

1.07E-09

4.49E-04

-----+----

0.474

10

0.047

2

97359879

FER1L5

0

Open Sea

cg00510149

−0.00134

0.00025

−0.0018;−0.0008

9.56E-08

4.01E-02

--+-------

0.531

10

0.023

11

10674966

IRAG1

0

Open Sea

cg02286857

−0.00134

0.00025

−0.0018;−0.0008

1.11E-07

4.66E-02

---------?

0.602

9

0.010

2

47297177

TTC7A

0

Open Sea

cg03603866

0.00129

0.00023

0.0008; 0.0017

1.16E-08

4.87E-03

+-+-++?+++

0.167

9

0.294

13

107027625

LINC00460

1284

Open Sea

cg04724807

−0.00179

0.00029

−0.0024;−0.0012

9.12E-10

3.83E-04

-+--------

0.391

10

0.097

14

62396305

SYT16

57496

Open Sea

cg05590755

−0.00080

0.00015

−0.0011;−0.0005

1.19E-07

4.99E-02

--+-------

0.439

10

0.066

1

23855149

E2F2

0

North Shore

cg05965490

−0.00132

0.00025

−0.0018;−0.0008

1.16E-07

4.87E-02

--+-------

0.398

10

0.092

8

30264627

RBPMS

0

Open Sea

cg08129759

−0.00077

0.00014

−0.0010;−0.0005

8.09E-08

3.39E-02

----------

0.303

10

0.166

1

202091944

GPR37L1

83

Open Sea

cg08219219

−0.00112

0.00017

−0.0014;−0.0008

5.05E-11

2.12E-05

----------

0.361

10

0.119

19

15337971

EPHX3

0

South Shelf

cg08539067

−0.00049

0.00009

−0.0007;−0.0003

2.84E-08

1.19E-02

--+----+--

0.491

10

0.039

3

49395985

GPX1

193

South Shore

cg09126859

−0.00106

0.00019

−0.0014;−0.0007

3.17E-08

1.33E-02

--+-------

0.415

10

0.081

12

52244063

FIGNL2

18361

South Shore

cg09167414

−0.00152

0.00028

−0.0021;−0.0010

3.31E-08

1.39E-02

----------

0.000

10

0.511

1

16076206

TMEM82

1913

South Shelf

cg12613632

−0.00088

0.00016

−0.0012;−0.0006

3.33E-08

1.40E-02

------+---

0.165

10

0.292

1

95385935

CNN3

0

Open Sea

cg14051770

−0.00162

0.00029

−0.0022;−0.0010

3.58E-08

1.50E-02

----------

0.000

10

0.833

7

76054572

ZP3

0

Open Sea

cg14143441

−0.00174

0.00031

−0.0023;−0.0011

1.55E-08

6.50E-03

--+-------

0.513

10

0.030

8

134387493

NDRG1

77945

Open Sea

cg14163484

−0.00085

0.00015

−0.0012;−0.0005

4.13E-08

1.73E-02

----?--?--

0.224

8

0.251

2

97359926

FER1L5

0

Open Sea

cg14244402

−0.00170

0.00032

−0.0023;−0.0011

1.10E-07

4.61E-02

----------

0.122

10

0.330

9

130681102

ST6GALNAC4

1796

South Shore

cg14704941

0.00196

0.00032

0.0013; 0.0026

5.33E-10

2.24E-04

++++++++??

0.432

8

0.090

11

19224659

CSRP3

0

Open Sea

cg15258080

−0.00129

0.00022

−0.0017;−0.0008

7.91E-09

3.32E-03

----------

0.419

10

0.078

10

71091204

HK1

0

Open Sea

cg15933729

−0.00079

0.00014

−0.0011;−0.0005

4.84E-09

2.03E-03

-+--------

0.182

10

0.276

11

27504612

LGR4

10277

Open Sea

cg16310415

0.00172

0.00032

0.0011; 0.0023

4.99E-08

2.09E-02

++++-++-+?

0.550

9

0.023

8

25898539

PPP2R2A

0

North Shore

cg16724070

−0.00163

0.00030

−0.0022;−0.0010

8.22E-08

3.45E-02

--+----+-?

0.605

9

0.009

1

183133736

LAMC1

19008

Open Sea

cg20042798

−0.00052

0.00010

−0.0007;−0.0003

7.95E-08

3.33E-02

----------

0.000

10

0.827

3

13036713

IQSEC1

0

South Shore

cg22673972

−0.00085

0.00015

−0.0011;−0.0005

3.12E-08

1.31E-02

----------

0.000

10

0.949

3

14415346

SLC6A6

28728

Open Sea

cg23696550

−0.00131

0.00024

−0.0018;−0.0008

5.80E-08

2.43E-02

-----+----

0.136

10

0.318

14

24732386

TGM1

0

Open Sea

cg24893073

−0.00061

0.00012

−0.0008;−0.0004

1.04E-07

4.36E-02

----------

0.000

10

0.845

17

7742126

KDM6B

1107

N_Shelf

cg26433445

−0.00086

0.00015

−0.0011;−0.0006

3.92E-09

1.64E-03

----------

0.571

10

0.013

16

81764289

CMIP

18921

Open Sea

  1. Beta: effect size, SE: Standard error, 95%CI: 95% confidence interval, Adjusted P-value: Bonferroni corrected p-value, HetISq: Heterogeneity test statistic I2, HetDf: Heterogeneity degrees of freedom, HetPVal: Heterogeneity test p-value. Direction: direction of the effect in each cohort, ordered in alphabetical order (+: positive; -: negative; and ?: CpG not present in the cohort).
  2. CpGs that were not annotated with a gene name in the Illumina 450 K annotation file have been annotated with their closest gene.
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