Fig. 5: Integrin is a key mechanosensing protein in cTnI-G203S myocytes. | Communications Biology

Fig. 5: Integrin is a key mechanosensing protein in cTnI-G203S myocytes.

From: A maladaptive feedback mechanism between the extracellular matrix and cytoskeleton contributes to hypertrophic cardiomyopathy pathophysiology

Fig. 5

a Compressive stiffness (in kPa) of cardiac myocytes isolated from cardiomyopathic cTnI-G203S mice and wt counterparts plated on soft and stiff hydrogels, including mean ± SEM. b–g Representative images and quantitated data points for cTnI-G203S cardiac myocytes plated on stiff and soft hydrogels stained for lamin A (b, c), vinculin (d, e), and integrin (f, g), including mean ± SEM. n = number of cells, N = number of gels. All statistical significance determined by Mann Whitney tests, or by Kruskal-Wallis test (a).

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