Fig. 3: Comparison of OF and IF states of bovine AE1.
a Superposed atomic models of OF and IF states showing significant conformational rearrangements of the core domain. In the IF state, TM11 extends significantly (red cylinder). Gate domain (purple), IF core domain (salmon) and OF core domain (yellow). b Comparison of OF and IF states of AE1 demonstrating downward movement with some rotational motion of the core domain with respect to the gate domain during the OF to IF transition (see also Supplementary Movies 1–3). Cα atoms of previously identified core residues from the central S1 site27 are shown as cyan spheres. The inset illustrates the difference in TM11 in the OF and IF state. c Surface models of the OF and IF structures. The OF and IF cavities are indicated with arrows.
