Fig. 6: Reorganization of TM11 and IL5 during IF to OF transition in AE1. | Communications Biology

Fig. 6: Reorganization of TM11 and IL5 during IF to OF transition in AE1.

From: CryoEM structures of anion exchanger 1 capture multiple states of inward- and outward-facing conformations

Fig. 6

Representative structures from MD simulations demonstrating changes in the area of TM10, IL5, and TM11 during the transition from IF to OF state: IF structure, showing the elongated TM11 (left, salmon helices); occluded-like state obtained during MD simulation after TM10 moves within the IF cavity (see Supplementary Videos 4,5) and TM11 bends at R778 (center, white helices); OF state demonstrating β-hairpin organization of IL5 (right, yellow helices and β-hairpin). The backbone atoms of IL5 forming the β-sheet are also shown as an inset. The H-bond networks between relevant residues are shown with dashes. Relevant residues studied with functional mutagenesis in this work or implicated in pathological states, are shown as sticks.

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