Fig. 1: 3D reconstruction of α7-ECD/α-Bgtx complex determined by cryo-EM. | Communications Biology

Fig. 1: 3D reconstruction of α7-ECD/α-Bgtx complex determined by cryo-EM.

From: Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors

Fig. 1

a Representative 2D class averages for α7-ECD without and with α-Bgtx. Scalebar is 10 nm. b, c Final 3D density map of the α7-ECD/α-Bgtx complex colored with local resolution in top and side views. d, e Crystal structure of the α7-ECD/α-Bgtx complex (PDB ID: 4HQP15) is shown for comparison in the same orientation as b, c. Five subunits of α7-ECD and five α-Bgtx molecules are differently colored. The position of the toxin’s loops I and III and expected position of membrane interface in the full-length channel are shown.

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