Fig. 5: Dynamic changes in circulating Vδ1 and Vδ2 γδ T cell subsets and association with BAL viral loads during early SARS-CoV-2 infection. | Communications Biology

Fig. 5: Dynamic changes in circulating Vδ1 and Vδ2 γδ T cell subsets and association with BAL viral loads during early SARS-CoV-2 infection.

From: The dynamics of γδ T cell responses in nonhuman primates during SARS-CoV-2 infection

Fig. 5

a Representative FACS plot of PBMC showing gating for Vδ1 and Vδ2 γδ T cell subsets in CD3 + T lymphocytes. b Frequencies of Vδ1 (left) and Vδ2 T cell subset (right) in PBMC following SARS-CoV-2 infection via aerosol or IT/IN routes (n = 8/group) on days 0, 1, 3, 7, 14, 21, and 28. Expression levels of HLA-DR, CXCR3, CCR6, and GrB on Vd1 T cells (c), and Vd2 T cells (d). Graphs show mean and SEM. Comparisons of different time points with respect to d0 baseline data were done using two-way ANOVA with mixed effects model and Dunnett’s post hoc tests. Asterisks indicate significant differences between time points (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001). Spearman Rank correlation between BAL viral loads in the first week (d1 and d7) with corresponding frequencies of Vδ1 T cells (e), and Vδ2 T cells (f) showing significant correlations for Vδ1 T cells in both aerosol and IT/IN groups (n = 16/group). Individual values shown for each animal as symbols in orange for RMs and blue for AGMs.

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