Table 1 P-values and effect sizes of prioritized genes.
From: Rare variant analyses across multiethnic cohorts identify novel genes for refractive error
Meta-analysis | Discovery set | Replication sets | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Multiethnic P-values | IECC P-values | EACC P-values | BDES P-values | EPIC-Norfolk P-values | REHS P-values | |||||||||||||
Gene | CMC | VT | ACAT | CMC (beta) | VT | ACAT | CMC (beta) | VT | ACAT | CMC (beta) | VT | ACAT | CMC (beta) | VT | ACAT | CMC (beta) | VT | ACAT |
PDCD6IP | 2.45e−7 | 1e−7 | 4.9e−6 | 3.4e−6 (0.0095) | 1.3e−5 | 5.6e−4 | 0.002 (−0.76) | 4.1e−4 | 5.5e−4 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
PER3 | 0.08 | 0.03 | 1e−6 | 0.14 (0.17) | 0.04 | 0.05 | 0.27 (0.16) | 0.55 | 0.12 | 0.51 (−0.2) | 0.42 | 0.48 | 0.43 (−0.11) | 0.11 | 0.22 | 0.02 (−0.52) | 0.04 | 1.2e−7 |
USH2A | 0.44 | 0.90 | 1.3e−5 | 0.82 (0.01) | 0.96 | 0.67 | 0.38 (−0.08) | 0.75 | 7.6e−9 | 0.78 (−0.05) | 0.72 | 0.35 | 0.33 (0.08) | 0.90 | 0.98 | 0.08 (0.22) | 0.19 | 0.81 |
MAPT | 0.02 | 8.6e−7 | 0.57 | 0.02 (−0.43) | 0.17 | 0.18 | 0.15 (0.31) | 0.19 | 0.37 | 0.43 (−0.5) | 0.44 | 0.24 | 0.48 (−0.17) | 0.04 | 0.87 | 0.01 (−0.8) | 1e−7 | 0.94 |
GRHL2 | 0.47 | 1.4e−6 | 0.06 | 0.31 (0.33) | 0.008 | 0.08 | NA | NA | NA | 0.87 (−0.19) | 0.86 | 0.08 | 0.39 (−0.55) | 0.38 | 0.39 | 0.21 (0.87) | 3e−7 | 0.21 |
CHST6 | 0.19 | 9e−7 | 0.06 | 0.58 (−0.09) | 2e−7 | 0.40 | 0.38 (0.21) | 0.56 | 0.58 | 0.05 (0.96) | 0.009 | 0.01 | 0.27 (0.27) | 0.09 | 0.16 | 0.35 (0.42) | 0.6 | 0.42 |
P4HTM | 0.09 | 1.7e−5 | 0.16 | 0.39 (0.01) | 0.24 | 0.10 | 0.005 (−2.02) | 1e−7 | 0.14 | 0.34 (0.61) | 0.29 | 0.19 | 0.49 (−0.16) | 0.51 | 0.54 | 0.83 (−0.12) | 0.56 | 0.57 |
