Table 2 Most important pathways to discriminate Nunavik gut microbiome composition from comparison groups, identified by random forest, ranked based on median Gini importance.

From: Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts

Rank

Pathways

Median (and SD) Gini importance

1

PWY-5103: L-isoleucine biosynthesis III | g__Eubacterium.s__Eubacterium_eligens

0.0032 ± 0.0016

2

PWY-7539: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)|unclassified

0.0027 ± 0.0017

3

BRANCHED-CHAIN-AA-SYN-PWY: superpathway of branched amino acid biosynthesis|g_Eubacterium.s Eubacterium_eligens

0.0026 ± 0.0012

4

PWY-6151: S-adenosyl-L-methionine cycle I | g__Prevotella.s__Prevotella_sp_AM42_24

0.0025 ± 0.0016

5

PWY-6168: flavin biosynthesis III (fungi)|g__Anaerostipes.s__Anaerostipes_hadrus

0.0023 ± 0.0016

6

COA-PWY: coenzyme A biosynthesis I | g__Prevotella.s__Prevotella_copri

0.0023 ± 0.0015

7

PWY-2942: L-lysine biosynthesis III | g__Prevotella.s__Prevotella_copri

0.0023 ± 0.0015

8

PWY-7111: pyruvate fermentation to isobutanol (engineered)|g__Prevotella.s__Prevotella_sp_AM42_24

0.0022 ± 0.0015

9

DTDPRHAMSYN-PWY: dTDP-L-rhamnose biosynthesis I | g__Prevotella.s__Prevotella_sp_AM42_24

0.0022 ± 0.0020

10

TEICHOICACID-PWY: teichoic acid (poly-glycerol) biosynthesis

0.0022 ± 0.0017

11

PWY-6147: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I | unclassified

0.0021 ± 0.0011

12

PWY-6151: S-adenosyl-L-methionine cycle I | g__Prevotella.s__Prevotella_copri

0.0020 ± 0.0013

13

PWY-5097: L-lysine biosynthesis VI | g__Prevotella.s__Prevotella_copri

0.0020 ± 0.0016

14

PYRIDOXSYN-PWY: pyridoxal 5’-phosphate biosynthesis I | unclassified

0.0020 ± 0.0012

15

PWY0-845: superpathway of pyridoxal 5’-phosphate biosynthesis and salvage|unclassified

0.0020 ± 0.0013

16

PWY-7219: adenosine ribonucleotides de novo biosynthesis

0.0020 ± 0.0013

17

POLYAMSYN-PWY: superpathway of polyamine biosynthesis I | unclassified

0.0020 ± 0.0010

18

PWY-3781: aerobic respiration I (cytochrome c)

0.0020 ± 0.0015

19

PWY-6703: preQ0 biosynthesis|g__Prevotella.s__Prevotella_copri

0.0019 ± 0.0018

20

ILEUSYN-PWY: L-isoleucine biosynthesis I (from threonine)|g__Eubacterium.s__Eubacterium_eligens

0.0019 ± 0.0016

  1. (SD: standard deviation).
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