Table 1 Cluster information of the global connectivity analysis results in cosmonauts.

From: Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity

Contrast/Brain region

 

Peak voxel coordinates

cluster size

beta

T-value

p-cFWE

  

x

y

z

    

Postflight>Preflight [−1 1] (df=14)

No significant results

Preflight>Postflight [1 −1] (df=14)

Precuneus/Posterior cingulate cortex, L

−12

−52

34

146

0.63

6.04

0.012

Sustain model, increases [−1 0.5 0.5] (df=10)

Angular gyrus/Supramarginal gyrus, R

54

−46

46

104

0.59

7.13

0.042

Sustain model, decrease [1 −0.5 −0.5] (df=10)

Precuneus/posterior cingulate cortex, L

−12

−52

34

123

0.61

6.62

0.016

Thalamus, L

00

−20

10

117

0.48

8.92

0.021

Normalize model, increases [−0.5 1 −0.5] (df=10)

No significant results

Normalize model, decreases [0.5 −1 0.5] (df = 10)

Posterior Insular cortex, L

−36

−16

00

169

0.60

7.26

0.003

Anterior Insular cortex, R

48

02

−06

140

0.62

6.73

0.011

  1. Peak voxels of clusters showing modulations in ICC values between various contrasts among the three scanning sessions in the cosmonaut cohort (preflight, postflight, follow-up). Brain region labeling was based on the Neuromorphometrics atlas. Beta values represent the effect size; T-values are cluster-averaged; p-cFWE: p-value after cluster-wise family-wise error (FWE) correction. This threshold was set at p < 0.05. df = degrees of freedom. R = right, L = Left. Bold fonts are used as headers to define the exact test that was performed.