Fig. 4: ELE results in novel transcriptomic changes in hippocampal neurons during adolescence. | Communications Biology

Fig. 4: ELE results in novel transcriptomic changes in hippocampal neurons during adolescence.

From: Early-life exercise primes the murine neural epigenome to facilitate gene expression and hippocampal memory consolidation

Fig. 4

a Volcano plot of differentially expressed genes reaching significance identified by TRAP-seq on ELE versus sedentary (n = 2 sedentary mice and n = 3 ELE mice, absolute value log2 fold change >0.3785 and p-value < 0.05). b Panther Gene Ontology: Molecular Function top terms by most genes assigned. c Top 6 “Upstream Regulators” identified by Ingenuity Pathway Analysis (IPA). d Representative Gene Set Enrichment Analysis: Reactome leading-edge diagrams showing genes upregulated (d) or downregulated (d′) in ELE, and their categories of enrichment. *Abbreviated terms in d: (1) “transport of mature mRNAs derived from intronless transcripts”, d′: (2) “activation of the mRNA upon binding of the cap binding complex and EIFs and subsequent binding to 43S”, (3) srp-dependent cotranslational protein targeting to membrane, and (4) response of eif2ak4 gcn2 to amino acid deficiency.

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