Fig. 6: The plant virus TuMV targets host proteins with higher expression levels.
From: A binary interaction map between turnip mosaic virus and Arabidopsis thaliana proteomes
a Virus–host protein–protein interactome contextualizing gene expression data (from healthy A. thaliana). Three expression levels are categorized. Host proteins whose expression significantly changes upon TuMV infection are represented by bigger nodes (+indicates upregulation, −downregulation). b, c Comparison between the actual Affymetrix expression distribution (from virus targets) and a representative null distribution (from randomly picked genes). *Statistical significance (Mann–Whitney U test, P < 0.05). The inset shows the distribution of P values after 1000 random realizations, with geometric mean <10−10 (in both cases). Expression levels corresponding to b a healthy or c an infected plant. d Scatter plot between the connectivity degree and differential expression (virus targets in red). Virus targets that are close to the soft Pareto front (blue line) are highlighted, indicating in parenthesis the corresponding virus protein.
