Fig. 1: Characterization of the intermolecular interactions and structure between azurin and p53. | Communications Biology

Fig. 1: Characterization of the intermolecular interactions and structure between azurin and p53.

From: Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination

Fig. 1

a Domain organization of human p53 and pseudomonas aeruginosa azurin. b Structure of azurin shown as cartoon (colored medium violet). Azurin p28 (colored dark cyan) and CT-p26 regions (colored marine) are highlighted. c The site of azurin interacting with p53 determined by solution NMR. Key residues with chemical shift perturbations are colored in orange. Azurin is rendered as surface colored medium violet. d The azurin binding site on p53-DBD (colored medium violet) determined by NMR titration. p53-DBD is rendered as surface and colored in orange. e Crystal structure of the azurin in complex with p53-DBD shown as a spacing-filling style. The two p53-DBD molecules are colored in orange and silver, and one azurin molecule is colored in medium violet. f Cartoon representation of the azurin-p53 structure.

Back to article page