Fig. 2: Temporal differential expression and splicing signatures and trajectories. | Communications Biology

Fig. 2: Temporal differential expression and splicing signatures and trajectories.

From: A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients

Fig. 2

a, b Numbers of differentially expressed and spliced genes between control and disease at fixed sacrifice days (DSS hit/rest cycle). c Subset of differentially expressed genes with unique disease-specific temporal trajectories, which are clustered into five dominant classes each with 133–194 genes as indicated. Volcano plot depicting the change in log fold change between days 5 and 12 as a function of p value. Gene label colors match cluster membership. Horizontal line depicts 5% FDR threshold. d Orthogonality of disease-specific differential splicing and expression temporal profiles.

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