Fig. 4: circCEBPZOS acts as a molecular sponge for miR-1178-3p. | Communications Biology

Fig. 4: circCEBPZOS acts as a molecular sponge for miR-1178-3p.

From: Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis

Fig. 4

a miRNA targets of circCEBPZOS were predicted by CircInteractome. b Expression of miR-614, miR-587, miR-1290 and miR-1178-3p in the EVs of serum from patients with and without postinfarct cardiac remodeling detected using qRT–PCR. Data are mean ± SD. **P < 0.01, N-CR group vs. Control group; ##P < 0.01, CR group vs. N-CR group. CR, postinfarct cardiac remodeling; N-CR, nonpostinfarct cardiac remodeling. c Dual luciferase reporter system analysis to detect the regulatory effect of miR-1178-3p on circCEBPZOS. d Expression of miR-1178-3p detected in VSMCs coincubated with EVs harboring with Over-circCEBPZOS or Sh-circCEBPZOS, U6 served as control. Data are mean ± SD. **P < 0.01, Over-circCEBPZOS group vs. NC group; ##P < 0.01, Sh-circCEBPZOS vs. NC group.

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