Fig. 5: miR-1178-3p inhibited angiogenesis of CMECs and proliferation and migration of VSMCs. | Communications Biology

Fig. 5: miR-1178-3p inhibited angiogenesis of CMECs and proliferation and migration of VSMCs.

From: Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis

Fig. 5

a Expression of miR-1178-3p was detected using qRT–PCR in CMECs treated with miR-1178-3p mimics or inhibitors; b Tube formation analysis to detect capillary-like structures in the miR-1178-3p mimic group or miR-1178-3p inhibitor group and rescued by circCEBPZOS, Bar = 200 μm; c CCK-8 assay was used to detect the viability of VSMCs in the miR-1178-3p mimics or miR-1178-3p inhibitor group and rescued by circCEBPZOS at 24 h, 48 h and 72 h; d Flow cytometry was used to detect the cell cycle of VSMCs in the miR-1178-3p mimics or miR-1178-3p inhibitor group and rescued by circCEBPZOS; e Migration of VSMCs was detected by Transwell assay when miR-1178-3p was overexpressed or suppressed and rescued by circCEBPZOS, Bar = 200 μm. Data are mean ± SD. **P < 0.01, miR-1178-3p mimics group vs. NC group; ##P < 0.01, miR-1178-3p inhibitor group vs. Control group.

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