Fig. 8: circCEBPZOS alleviated postinfarct cardiac remodeling. | Communications Biology

Fig. 8: circCEBPZOS alleviated postinfarct cardiac remodeling.

From: Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis

Fig. 8

a qRT–PCR was used to verify the expression of circCEBPZOS in heart tissue treated with exosomal circCEBPZOS. GAPDH served as a control. b Echocardiographic measurements to detect the in the model group compared with sham group; c Pathological changes detected by HE, Masson and Sirius Red staining in heart tissue treated with circCEBPZOS, Bar = 50 μm; d Western blotting analysis to detect the expression of HIF-1α, VEGF and VEGFR in the Over-circa-Exo group or Sh-circa-Exo group. GAPDH served act as control; e Immunofluorescence staining was used to detect the expression of HIF-1α, VEGF and VEGFR in the Over-circa-Exo group or Sh-circa-Exo group. DAPI was used to stain the nuclei; Bar = 50 μm. Data are mean ± SD. **p < 0.01, Over-circ-Exo group vs. MI-NC group; ##p < 0.01, She-circ-Exo group vs. MI-NC group.

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