Fig. 2: TNBC proliferation is promoted by mammary gland fat pad (MGFP) and MGTRMs in vitro. | Communications Biology

Fig. 2: TNBC proliferation is promoted by mammary gland fat pad (MGFP) and MGTRMs in vitro.

From: Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases

Fig. 2

a 4T1 and E0771 cells carrying luciferase reporter genes were co-cultured with MGFP treated with PBS liposomes (PL) or clodronate liposomes (CL) for 3 days. Luciferase activity of TNBC cells was normalized by the luciferase activity of corresponding monocultured TNBC cells. n = 3. *p < 0.05, **p < 0.01, ***p < 0.001 (t-test). b 4T1 and E0771 cells carrying luciferase reporter genes were co-cultured with MGTRMs for 3 days. Luciferase activity of TNBC cells was normalized by the luciferase activity of corresponding monocultured TNBC cells. n = 3. *p < 0.05, **p < 0.01 (t-test). c Luciferase activity of 4T1/Fluc and E0771/mKO2-luc2 cells cultured with (+) or without (−) CL for 3 days was measured and their relative light units (RLU) are shown. n = 4. ns not significant (t-test). a–c Error bars indicate s.e.m.

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