Fig. 4: Functional genomic basis of H/L values in chickens. | Communications Biology

Fig. 4: Functional genomic basis of H/L values in chickens.

From: A heterophil/lymphocyte-selected population reveals the phosphatase PTPRJ is associated with immune defense in chickens

Fig. 4

a GWAS revealed strong association of chicken H/L with a 1-Mb region on chromosome 5. b Fixation index (Fst) between G9 and NS chickens for all SNPs along the 1-Mb region. c Nucleotide diversity (Pi) of G9 (blue line) and NS chickens (red line) from 12.4 to 13.3 Mb on chromosome 5. d Schematic overview of PTPRJ function. e mRNA expression of PTPRJ by RNA-seq in individuals having high and low PTPRJ expression. f mRNA expression of LYN, SHP-1, and SHIP-1 by RNA-seq in individuals having high and low PTPRJ expression. The indicated significance (**) is based on one-way ANOVA, ns: not significant (p > 0.05). Data are expressed as the mean ± standard deviation (SD).

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