Fig. 5: CircFNDC3B functions by targeting miR-525-5p.
From: CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
a, b RT-qPCR analysis of Collagen II, Aggrecan, MMP3, and MMP13 when HCs were overexpression or knockdown of miR-525-5p. (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test. c Western blot analysis of Collagen II, Aggrecan, MMP3, and MMP13 when HCs were overexpression or knockdown of miR-525-5p. d–f RT-PCR, western blot and CCK-8 assay showed that the downregulation of miR-525-5p antagonized the effect of si-CircFNDC3B on Collagen II, Aggrecan, MMP3, and MMP13 in HCs. (n = 3). RT-PCR results: *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test. CCK-8 assay results: **p < 0.01 by ANOVA.
