Fig. 6: PARP1 inhibition induces telomere fragility. | Communications Biology

Fig. 6: PARP1 inhibition induces telomere fragility.

From: PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

Fig. 6

a HeLa were transfected as indicated and after 72 hours metaphases were collected and processed for FISH analysis with pantelomeric/pancentromeric staining and counterstained with DAPI. Representative images at 100× magnification are shown. b Telomere doublets were scored and reported in graphs as the number of doublets/chromosomes. Three pulled independent experiments were plotted, 100 metaphases per sample were scored, red bars are means, P value was determined by unpaired two tailed t-student test. **P ≤ 0.01, ****P ≤ 0.0001.

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