Fig. 4: Mode of action of P218 on sporozoite hepatocyte invasion and schizont maturation. | Communications Biology

Fig. 4: Mode of action of P218 on sporozoite hepatocyte invasion and schizont maturation.

From: Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

Fig. 4

Plasmodium falciparum NF175 sporozoites/infected HC10-10 hepatocytes were incubated with serial dilutions according to the scheme indicated on the left of the figure. Blue bars indicate the presence of the compound, with daily refreshments for longer incubations. The table indicates IC50 values determined in two independent experiments, with two replicates per experiment. In addition, the table lists the maximum reduction in parasite numbers that were achieved (plateau of the dose-response curve), and the relative sizes of remaining parasites in comparison with vehicle controls (0.1% DMSO).

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