Table 1 IC50 values of selected compounds in P. falciparum NF54 sporozoite functional assays.
IC50 values (nM) | |||||||
|---|---|---|---|---|---|---|---|
MMV code | Class | Name | ABS | Spz viability | Spz gliding | Spz traversal | Liver stage |
MMV659065 | 4-aminoquinolines | N-desethyl amodiaquine | 12 | 1635 | 1510 | 472 | 1146 |
MMV675052 | HMT | BIX-01294 | 75 | 3772 | >10,000 | 4021 | <5000 |
MMV000017 | 4-aminoquinolines | Naphthoquine | 3.2 | 4363 | 2921 | 1094 | >5000 |
MMV000001 | 4-aminoquinolines | Amodiaquine | 3.9 | 6311 | 2325 | 230 | 3759 |
MMV000025 | 4-aminoquinolines | Pyronaridine | 4.9 | 6471 | 836 | 458 | 869 |
MMV000018 | 8-aminoquinolines | NPC-1161B | 419 | 7569 | 9808 | >10,000 | 1454 |
MMV000043 | 8-aminoquinolines | Tafenoquine | 631 | 8614 | >10,000 | >10,000 | 930 |
MMV000013 | 4-aminoquinolines | Hydroxychloroquine | 16 | >10,000 | >10,000 | >10,000 | >5000 |
MMV000023 | 8-aminoquinolines | Primaquine | 1191 | >10,000 | >10,000 | >10,000 | 235.0 |
MMV000063 | 8-aminoquinolines | Sitamaquine | >10,000 | >10,000 | >10,000 | 412.0 | |
MMV000030 | Antibiotics | Thiostrepton | 388 | >10,000 | >10,000 | >10,000 | 1349 |
MMV000147 | Antifolates | P218 | >10,000 | >10,000 | >10,000 | 0.3 | |
MMV000052 | Antifolates | Cycloguanil | 4.5 | >10,000 | >10,000 | >10,000 | 3.4 |
MMV000024 | Antifolates | Pyrimethamine | 17 | >10,000 | >10,000 | >10,000 | 37.0 |
MMV000028 | Antifolates | Trimethoprim | 940 | >10,000 | >10,000 | >10,000 | 292.0 |
MMV000065 | Antifolates | Methotrexate | >10,000 | >10,000 | >10,000 | 569.2 | |
MMV000046 | BC1 | Atovaquone | 0.6 | >10,000 | >10,000 | >10,000 | 8.3 |
MMV034055 | BC1 | ELQ-300 | 4.8 | >10,000 | >10,000 | >10,000 | 110.2 |
MMV674751 | CARL | KAF-156 | >10,000 | >10,000 | >10,000 | 16.2 | |
MMV669059 | DHODH | DSM421 | >10,000 | >10,000 | >10,000 | 505.0 | |
MMV643121 | EF2 | DDD498 | 1 | >10,000 | >10,000 | >10,000 | 1.1 |
MMV000005 | Endoperoxide | Artesunate | 3.5 | >10,000 | >10,000 | >10,000 | >10,000 |
MMV884705 | NMT | NMT-145 | >10,000 | >10,000 | >10,000 | 430.0 | |
MMV675867 | Other | AN13762 | >10,000 | >10,000 | >10,000 | 5.9 | |
MMV000031 | Other | Cyclohexamide | >10,000 | >10,000 | >10,000 | 843.8 | |
MMV000062 | Other | Pentamidine | >10,000 | >10,000 | >10,000 | 974.9 | |
MMV000061 | Other | Methylene blue | NA | >10,000 | 3279 | 3522 | >5000 |
MMV642944 | PI4K | UCT944 | >10,000 | >10,000 | >10,000 | 1.4 | |
MMV642943 | PI4K | UCT943 | NA | >10,000 | >10,000 | >10,000 | 4 |
MMV390048 | PI4K | UCT048 | 28 | >10,000 | >10,000 | >10,000 | 45.1 |
MMV674253 | Vacuolar ATPase | AZ412 | 12 | >10,000 | >10,000 | >10,000 | 3040 |
