Table 1 Clinical data, mean fibril height and length values obtained from AFM analysis of CSF of the studied patients.

From: Protein fibril length in cerebrospinal fluid is increased in Alzheimer’s disease

Patient ID

Age

Diagnosis

Fibril Length in CSF (µm)

Fibril Height in CSF (nm)

Aβ42/40 ratio

p-Tau [ng/l]

t-Tau [ng/l]

MoCA score [0–30]

KSSG-2

70

MCI AD

0.5 ± 0.25

3.1 ± 0.7

0.041

138

850

24

KSSG-15

53

ADD

2.1 ± 0.35

2.9 ± 1.1

0.043

76

545

20

KSSG-19

58

SCD

0.3 ± 0.2

2.7 ± 1.2

0.089

25

146

27

KSSG-20

75

PDD

0.5 ± 0.2

1.5 ± 0.2

0.094

51

357

20

KSSG-31

81

ADD

1.9 ± 0.7

2.6 ± 0.4

0.042

161

846

11

KSSG-36

73

ADD

2.4 ± 0.5

4.3 ± 2

0.039

73

439

7

KSSG-37

61

MCI

0.45 ± 0.1

2.9 ± 0.3

0.1

28

189

20

KSSG-38

90

ADD

2.2 ± 0.75

3 ± 0.4

0.04

58

356

3

KSSG-40

84

ADD

2.25 ± 0.6

3.8 ± 1.7

0.064

64

435

20

KSSG-44

78

LBD

1.2 ± 0.3

2.2 ± 0.5

0.108

66

534

 

KSSG-46

76

SCD

0 ± 0

0 ± 0

0.073

37

324

25

KSSG-48

57

ADD

1.7 ± 0.5

4.2 ± 1.3

0.05

160

1077

19

KSSG-51

56

MCI AD

0.8 ± 0.25

2.4 ± 0.6

0.062

26

192

26

KSSG-54

79

MCI AD

1.3 ± 0.2

2.9 ± 0.4

0.038

86

580

21

KSSG-57

53

SCD

0.4 ± 0.2

2.2 ± 0.8

0.122

28

181

26

KSSG-66

76

VDD

0 ± 0

0 ± 0

0.084

47

401

25

KSSG-68

57

ADD

2.3 ± 0.4

4.3 ± 1.8

0.033

91

765

18

KSSG-71

61

MCI AD

0.75 ± 0.4

2.5 ± 0.2

0.039

44

387

30

KSSG-74

60

ADD

2.1 ± 0.4

4.1 ± 0.2

0.058

50

370

13

KSSG-77

71

MCI AD

1.2 ± 0.5

2.8 ± 0.3

0.027

188

1171

21

KSSG-83

77

MCI AD

1.45 ± 0.3

3.1 ± 0.1

0.035

102

801

20

KSSG-84

60

SCD

0.25 ± 0.1

1.5 ± 0.3

0.128

59

440

25

KSSG-86

76

ADD

2.1 ± 0.8

4.1 ± 1.6

0.062

47

866

20

KSSG-89

80

ADD

2.2 ± 0.5

3.5 ± 0.9

0.053

98

559

20

KSSG-90

72

MCI AD

1.7 ± 0.1

2.3 ± 0.6

0.048

88

448

22

KSSG-94

80

ADD

1.95 ± 0.2

3.8 ± 0.5

0.041

114

550

22

KSSG-97

60

SCD

0 ± 0

0 ± 0

0.068

37

174

29

KSSG−108

70

LBD

0.35 ± 0.1

1.9 ± 0.5

0.084

12

146

10

KSSG−114

90

MCI AD

1.5 ± 0.3

2.7 ± 0.4

0.037

108

660

20

KSSG−129

51

SCD

0.3 ± 0.1

1.8 ± 0.5

0.122

31

307

28

KSSG−136

60

MCI AD

0.8 ± 0.2

3 ± 0.2

0.05

96

543

 

KSSG−137

56

MCI AD

1.1 ± 0.4

2.8 ± 0.2

0.05

39

272

 

KSSG−138

69

SCD

0.3 ± 0.15

1.75 ± 0.4

0.084

36

298

27

  1. In the case of patients, KSSG:46, 66 and 97 no fibrillar aggregates were detected in their CSF. Fibril length and height were set to zero if no fibrils were detected. The fibril morphology detected using AFM and quantified in CSF from patients KSSG:19, 57, 84 and 129 were mainly protofibrillar aggregates with nodular morphology as shown in Fig. 3. The morphology of fibrils detected in CSF using AFM from the rest of the patients is summarised in Supplementary Table S1.
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