Fig. 7: Endogenous upregulation of REG3A in skeletal muscle is linked to improved metabolism after bariatric surgery in obese individuals. | Communications Biology

Fig. 7: Endogenous upregulation of REG3A in skeletal muscle is linked to improved metabolism after bariatric surgery in obese individuals.

From: Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice

Fig. 7

a, b REG3A mRNA expression level assessed from transcriptomes of indicated tissues in patients with metabolic disease. a NGT: normal glucose tolerance (Hb1Ac less than 6%); IGT: impaired glucose tolerance (HbA1c between 6 and 6.5%); T2D: type 2 diabetes (HbA1c greater than 6.5%); b IS: insulin-sensitive; IR insulin-resistant. IS et IR were defined by measuring the glucose disposal rate during an hyperinsulinemic euglycemic clamp in Wu et al. Endocrinology, et al. 2007. c–f Molecular changes over time in the vastus lateralis skeletal muscle of 16 patients who underwent bariatric surgery. c REG3A mRNA expression. d Gene enrichment of “Insulin signaling pathway” in KEGG. e Gene enrichment of “Activated AMPK stimulates fatty acid oxidation in muscle” in Reactome. f Spearman correlation between REG3A expression and enrichment score of the “mitochondrial uncoupling pathway” in Reactome. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.005 by Anova test followed by post-hoc test. NS or no statistical indication, no significance.

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