Fig. 3: T-cell infiltration in the aged mouse brain is reduced by CCR3 inhibition.
From: CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain
24-month-old male mice were treated with vehicle or AKST4290 for 5 weeks. a Representative images of CD3 T cells co-stained with CD45 and vessel marker Lectin in the subventricular zone (SVZ). b Average number of CD3+ T cells in the SVZ (*p < 0.05, unpaired t-test; n = 23, 22). c Representative images of CD3+ T cells co-stained with CD45+ macrophages and vessel marker Lectin in the hippocampus. d Average number of CD3+ T cells in the hippocampus (*p < 0.05, unpaired t-test; n = 18, 16). e Representative images of CD3+ T cells co-stained with CD45+ macrophages and vessel marker Lectin in the choroid plexus of the third ventricle. f Average number of CD3+ T cells in the choroid plexus (*p < 0.05, unpaired t-test; n = 21, 20). All data shown are mean ± standard error of the mean.
