Fig. 3: Knockdown of LFPRLR impacts early B-lymphopoiesis in SLE-prone mice. | Communications Biology

Fig. 3: Knockdown of LFPRLR impacts early B-lymphopoiesis in SLE-prone mice.

From: Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms

Fig. 3

a Quantitation and representative flow cytometry plots of bone marrow CD19+ B cells in MRL-lpr mice treated with control SMO (n = 9, red) or LFPRLR SMO (n = 9, blue). b Quantitation and representative histograms showing median fluorescence intensity (MFI) of BCL2 protein in bone marrow B cells of control SMO-treated (n = 5, red) and LFPRLR SMO-treated (n = 5, blue) MRL-lpr mice by flow cytometry. c A model depicting the mechanisms by which LFPRLR increases the number of abnormal splenic B cells available for potential malignant transformation or the concurrent worsening of autoimmune pathology in SLE-prone mice. Graphs show median ± interquartile range. Exact p-values were calculated using the Mann–Whitney U test. ns non-significant, FMO fluorescence minus one control. c was created with BioRender.com.

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