Fig. 3: Heart aberrations in Nsun3HKO mice. | Communications Biology

Fig. 3: Heart aberrations in Nsun3HKO mice.

From: NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

Fig. 3

a The mass of 14- and 50-week-old mice hearts that were dissected and measured after echocardiography. b Representative M-mode echocardiography images of 50-week-old Flox mice and Nsun3HKO mice. The upper images show the axis view of the left ventricle. Lower panels show the M-mode tracing of the left ventricle. c Schematic of diastolic stage and systolic stage of heart. d Left ventricle relative mass estimated by the echocardiography image analysis. e Left ventricle volume at diastolic stage (left panel) and systolic stage (right panel). f Calculated ejection fraction (%) of the hearts. g Left ventricle posterior wall thickness at diastolic stage (left panel) and systolic stage (right panel). Means ± s.e.m. from n = 3 mice (14-week-old Flox) or 4 mice (14-week-old Nsun3HKO, 50-week-old Flox and Nsun3HKO mice). **P < 0.01 and *P < 0.05 by two-way ANOVA followed by Tukey’s test.

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