Fig. 4: Morphological abnormalities of Nsun3HKO mouse heart mitochondria. | Communications Biology

Fig. 4: Morphological abnormalities of Nsun3HKO mouse heart mitochondria.

From: NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice

Fig. 4

a, b Representative images of mitochondria in cardiac muscles of 50-week-old Flox mice (a) and Nsun3HKO mice (b). Scale bar, 1 μm. c Histogram showing the size distribution of cardiac mitochondria from 14- or 50-week-old, Flox, or Nsun3HKO mice. n = 300 mitochondria in each group were analyzed. d Violin plot of the same data as shown in the histogram. The mean mitochondrial areas (Flox 14-wk, 0.690 μm2; HKO 14-wk, 1.011 μm2; Flox 50-wk, 0.685 μm2; HKO 50-wk, 1174 μm2) are indicated by horizontal lines. ****P < 0.0001 and *P < 0.05 by Mann–Whitney test.

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