Fig. 5: For models with significant CVRF × sex interaction, white matter microstructure associations with CVRFs shown separately for males (squares, n = 543) and females (triangles, n = 561). | Communications Biology

Fig. 5: For models with significant CVRF × sex interaction, white matter microstructure associations with CVRFs shown separately for males (squares, n = 543) and females (triangles, n = 561).

From: Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain

Fig. 5

MRI indices of tract-specific axonal density (ICVF), free water (ISOVF), myelin content (MTsat) and tract volume were analysed. Sex-specific models included age, age2 and total intracranial volume as covariates. The x-axis contains the 31 tracts-of-interest coloured and grouped, as in Fig. 1, by association tracts (shades of blue), projection tracts (brown), limbic tracts (pink/red) and corpus callosum (yellow/green). AF arcuate fasciculus, BMI body mass index, CC corpus callosum (1 = rostrum, 2 = genu, 3 = rostral body, 4 = anterior midbody, 5 = posterior midbody, 6 = isthmus, 7 = splenium), CG cingulum bundle, CST cortico-spinal tract, CVRF cardiovascular risk factor, FX fornix, ICVF intra-cellular volume fraction, IFO inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, ISOVF isotropic volume fraction, MLF middle longitudinal fasciculus, MTsat magnetization transfer saturation, OR optic radiation, SLF superior longitudinal fasciculus, UF uncinate fasciculus, WHR waist-to-hip ratio.

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