Table 1 Antimicrobial activity of vancomycin derivatives against Gram-positive bacteriaa.

From: Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

Compound

MIC (µg/mL)

S. aureus

S. pneumoniae

E. faecalis

E. faecium

ATCC 25923 Control

Clinical isolate MRSA

ATCC 43300 MRSA

NRS 17 GISA

NRS 1 GISA, MRSA

Clinical isolate MRSA, DRSA

VRS 3b VRSA

VRS 10 VRSA

ATCC 700677 MDR

ATCC 29212 Control

Clinical isolate VanA

ATCC 35667 Control

ATCC 51559 MDR-VanA

1 Vancomycin

2

2

1

8

8

2

64

>64

2

4

32

0.5

>64

2 Van-3C-N3

N/A

2

2

4

4

2

>64

>64

2

2

>64

1

>64

3 Van-8C-N3

N/A

0.5

0.5

2

2

0.5

16

64

0.5

0.5

32

0.25

32

4 Van-3PEG-N3

N/A

4

2

8

8

4

>64

>64

4

4

>64

1

>64

7 Van-8C-Tz-NBD

0.5

1

0.5

2

2

0.5

16

16

0.5

0.5

16

0.06

32

8 Van-8C-Tz-DMACA

0.5

1

0.5

2

4

1

32

32

1

0.5

16

0.125

32

9 Van-3PEG-Tz-NBD

2

4

2

8

8

2

>64

>64

2

4

>64

0.5

>64

  1. aFull strain descriptions detailed in Table S4. MIC was tested by broth microdilution in non-binding surface (NBS) 96-well micro-titre plates, n = 4 (2 independent duplicate experiments).
Back to article page