Fig. 2: Thermal stability of ACE2-IgG4-Fc.
From: Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2
a FUV CD spectra obtained at different temperatures. b Change in the CD signal at 222 nm during heating. DSC thermograms of ACE2-IgG4-Fc (c) without inhibitors or in the presence of (d) DX600 or (e) MLN4760. The concentration of ACE2-IgG4-Fc was 5 µM. f Melting temperatures of the ACE2 domain in ACE2-IgG4-Fc (5 µM) without inhibitor or with 50 µM inhibitor. The bars are mean values of triplicates. The error bar is the standard deviation. The circles depict the values from each replicate.
