Fig. 7: Human GIL-11 rescued IL-6R−/− mice from death following partial hepatectomy. | Communications Biology

Fig. 7: Human GIL-11 rescued IL-6R−/− mice from death following partial hepatectomy.

From: Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes

Fig. 7

a IL-6R−/− mice were subjected to 70% PHX, injected with PBS (n = 11) or GIL-11 (n = 11), 20 µg each, 24 h before and directly after surgery and survival was monitored for 9 days. b Body weight of IL-6R−/− mice treated with and without GIL-11 after 70% PHX was determined 12 days after PHX (n = 4 untreated, n = 5 GIL-11). c Liver/body weight ratio of IL-6R−/− mice treated with and without GIL-11 after 70% PHX was determined at 9 days after PHX (n = 5 untreated, n = 7 GIL-11). d Spleen weight of IL-6R−/− mice treated with and without GIL-11 after 70% PHX was determined at 9 days after PHX (n = 5 untreated, n = 7 GIL-11). e Total RNA was extracted from the liver directly after PHX from IL-6R−/− mice previously treated with and without GIL-11 and mRNA level of aSMA, SAA1, Ki67, EGF, CycA2 and G0S2 were determined by quantitative PCR (n = 6). b–e Each dot represent data derived from one mouse. Error bars are ±SEM.

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