Fig. 2: Signaling proteins upstream of neurofibromin.
From: The therapeutic potential of neurofibromin signaling pathways and binding partners
The APP and GM-CSFR, several RTKs and several GPCRs have been involved in neurofibromin signaling and with different biological consequences. Main cytosolic upstream regulators of neurofibromin include 14-3-3, FAK, PKC, PKA, DDAH1 and Spred1. Neurofibromin posttranslational modifications include phosphorylation and ubiquitination.
