Fig. 3: Signaling pathways downstream of neurofibromin.
From: The therapeutic potential of neurofibromin signaling pathways and binding partners
Neurofibromin is involved in several cell signaling pathways, including the Ras/MAPK, Akt/mTOR, Ral, ROCK/LIMK/cofilin, and cAMP/PKA pathways. From the cytosol to the nucleus neurofibromin regulates many fundamental cellular processes, such as expression of estrogen response genes, proliferation, migration, cortex development, learning and memory (L/M).
