Table 1 Index SNPs of novel loci associated with BMD.

From: Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis

rsID

CHR

BP

Location

Gene

A1

EAF

SK-Effect

P

eBMD-Effect

P

rs12107945

3

147163978

3q24

ZIC1

A

0.30

−0.049

1.37E-10

−2.3E-4

0.73

rs11993347

8

103919090

8q22.3

ATP6V1C1/AZIN1

T

0.77

0.059

2.67E-12

0.004

0.025

rs61863293*

10

132252499

10q26.3

GLRX3

A

0.35

−0.046

2.80E-08

0.002

0.16

rs71378928

17

66453305

17q24.2

PRKAR1A/WIPI1

C

0.23

−0.050

2.67E-09

0.003

0.24

  1. *Values for eBMD are reported for rs61861957 (r2 = 0.914). Gene names are shown in italic font.
  2. Variants associated with SK-BMD in the meta-analysis (N = 43,800) that map outside + /− 500 Kb of known index SNPs of genetic associations with different bone traits. Genomic coordinates are on build 37 of the human genome. Effect sizes and allele frequencies (EAF) are reported for the A1 allele. eBMD statistics are reported from Morris et al.4 meta-analysis comprising 426,824 individuals.
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