Fig. 2: Clinical course of fundus spot accumulation in Lipe−/− mice compared to Lipe+/+. | Communications Biology

Fig. 2: Clinical course of fundus spot accumulation in Lipe−/− mice compared to Lipe+/+.

From: Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis

Fig. 2

At 4–6 months of age, Lipe−/− mice show a clear increase in fundus spot accumulation compared to Lipe+/+ mice (b vs. a). As the mice age there is a progressive increase in fundus spots (c–h). The difference was statistically significant for all age groups (i). The experiment included Lipe−/− (n = 30, 42, 12 and 4 mice for age groups 4–<6, 8–<8, 8–<10, and 10–<13 months, respectively) and Lipe+/+ (n = 16, 21, 10 and 8 mice for age groups 4–<6, 8–<8, 8–<10, and 10–<13 months, respectively). Black scale bars = 200 μm. Data are shown as Mean ± SEM. Two-tailed Student’s t test. **p < 0.01, ***p < 0.001, ****p < 0.0001.

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