Fig. 2: cPA-producing activity of human GDE7 in cells. | Communications Biology

Fig. 2: cPA-producing activity of human GDE7 in cells.

From: GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

Fig. 2

The levels of LPA (a) and cPA (b) in control (–) and hGDE7-overexpressing (h7) COS-7 cells analyzed by LC-MS/MS. The levels of LPA (c) and cPA (d) analyzed with wild-type (WT) and GDE7-deficient (KO) MCF-7 cells and KO cells overexpressing mGDE7 (RE). The graphs present the total levels (left) and the levels of each molecular species (right). Bars represent mean values ± S.D (n = 3). Log transformed data were used for Dunnett’s test analysis. *P < 0.05, **P < 0.01 (COS-7, vs. (–); MCF-7, vs. KO). N.D., not detected.

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