Fig. 4: BP10MB[1] and SS[ > 7 & <=8] as potential biomarkers of HRD. | Communications Biology

Fig. 4: BP10MB[1] and SS[ > 7 & <=8] as potential biomarkers of HRD.

From: Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology

Fig. 4

a HRD prediction ROC curves of CNA feature BP10MB[1] in training and held-out datasets. b ROC curves showed the performance of CNA feature BP10MB[1] in three independent validation datasets with different sequencing platforms, a total of 633 cancer samples, including 66 breast cancer samples with WGS sequencing, 66 breast cancer samples with SNP array sequencing, and 501 pan-cancer cancer samples with panel sequencing. c BP10MB[1] count for 633 cancer samples is ordered from lowest to highest. d ROC curves of CNA feature SS[ > 7 & <=8] in training and held-out datasets. e ROC curves showed the performance of CNA feature SS[ > 7 & <=8] in three independent validation datasets. f SS[ > 7 & <=8] count for 633 cancer samples is ordered from lowest to highest.

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