Fig. 2: s-SNOM chemical mapping and TEM of myeloma cells.
From: Label-free nanoscale mapping of intracellular organelle chemistry
a s-SNOM chemical mapping of myeloma cells acquired at 1667 cm−1, targeting amide groups in proteins and nucleobases. Insets a(i) and a(ii) are higher-resolution s-SNOM images. b, c TEM of myeloma cells poststained with uranyl acetate and lead citrate but left non-osmicated. Insets c(i) and c(ii) show structures in greater detail. d Spatial profile of the s-SNOM signal along the red line in a(ii). NM nuclear membrane, Nuc nucleolus, ER endoplasmic reticulum, Mt mitochondria. Scale bars 2 µm (a, b), 1 µm (c) and 500 nm (a(i), a(ii), c(i), c(ii)).
